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Drugs acting on the Central Nervous System PDF Pharmacology Note Free Download For Pharmacy Students. Depression is an affective illness, whose pathomechanism is not completely known. It can have different degrees of intensity. Physiological depression may appear after a loss of a loved one, a change of the environment, a failure at work or school and many others. It is the mildest form of depression and it usually disappears spontaneously. Neurotic depression is caused by an emotional problem of which a person is not aware. In this type of depression psychotherapy is recommended, but sometimes treatment using antidepressants is effective.