There is no electron-withdrawing group, and so the penicillin is acid sensitive. As a result, it cannot be taken orally. The presence of the steric shields also makes it more difficult for the penicillin to attack the transpeptidase enzyme. This means that methicillin has a lower activity and a narrower spectrum of activity compared to penicillin G.
There is no electron-withdrawing group, and so the penicillin is acid sensitive. As a result, it cannot be taken orally. The presence of the steric shields also makes it more difficult for the penicillin to attack the transpeptidase enzyme. This means that methicillin has a lower activity and a narrower spectrum of activity compared to penicillin G.