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HMP Shunt Pathway Biochemistry Note Download Free For Pharmacy Students.
The pentose phosphate pathway (HMP) has two main functions
• Generation of NADPH
‐ mainly used for reductive syntheses of fatty acids, steroids, amino acids via glutamate dehydrogenase; and production of reduced glutathione in erythrocytes and other cells.
‐ active in liver, adipose tissue, adrenal cortex, thyroid, erythrocytes, testes, and lactating mammary gland
‐ not active in non‐lactating mammary gland and has low activity in skeletal muscle.
• Production of ribose residues for nucleotide and nucleic acid synthesis.