Download Pharmacogenetics PPT For Free. Pharmacogenetics is that the study of the genetic factors that influence drug response and toxicity.
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1. Overview of Pharmacogenetics PPT
- The study of genetically controlled variations in drug response.
- Pharmacogenetics is the special area of biochemical genetics that deals with variation in drug response and the contribution of genetics to such variation.
- Monogenic: due to allelic variation at a single gene
- Polygenic: due to variations at two or more gene
- Polymorphic: frequently occurring monogenic variants occurring at a frequency >1%
2. Pharmacogenetics and Pharmacogenomics
Contents of this PPT
- Background and Introduction
- Importance and Goals of Pharmacogenomics
- Pharmacogenetic Phenotypes
- Pharmacogenomic tests
- Pharmacogenetics & Drug development
- Pharmacogenetics in clinical practice
- Advantages and barriers of pharmacogenomics
3. Genetic Polymorphism in Drug Metabolism
- Genetic polymorphism is the variations in DNA sequences
- This explain some of the variability in drug- metabolizing enzyme activities which contribute to
- alterations in drug clearance and
- impact patients’ response to drug therapy
4. Drug Discovery and Development
- In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery
- But now we know diseases are controlled at molecular and physiological level
- Also shape of an molecule at atomic level is well understood.
- Information of Human Genome
5. Aptamers Based Drug Delivery
- Aptamers are oligonucleotide or peptide molecules that bind to specific target molecule.
- Aptamers are usually created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.
- Aptamers can be combined with ribozymes to self-cleave in the presence of their target molecule.
- They range in size from 20 to 80 bases (6-26kda).
6. Personalized Medicines
- Personalized medicine.
- Dosage forms for personalized medicine.
- Categories of patients for personalized medicine.
- Customized drug delivery systems.
- 3D printing of pharmaceuticals.
- Bioelectric Medicines
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