Free Download Pharmacogenetics PPT in

Download Pharmacogenetics PPT For Free. Pharmacogenetics is that the study of the genetic factors that influence drug response and toxicity.

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Free Download Pharmacogenetics PPT in 2021
Free Download Pharmacogenetics PPT

1. Overview of Pharmacogenetics PPT

  • The study of genetically controlled variations in drug response.
  • Pharmacogenetics is the special area of biochemical genetics that deals with variation in drug response and the contribution of genetics to such variation.
  • Monogenic: due to allelic variation at a single gene
  • Polygenic: due to variations at two or more gene
  • Polymorphic: frequently occurring monogenic variants occurring at a frequency >1%

2. Pharmacogenetics and Pharmacogenomics

Contents of this PPT

  • Background and Introduction
  • Importance and Goals of Pharmacogenomics
  • Pharmacogenetic Phenotypes
  • Pharmacogenomic tests
  • Pharmacogenetics & Drug development
  • Pharmacogenetics in clinical practice
  • Advantages and barriers of pharmacogenomics

3. Genetic Polymorphism in Drug Metabolism

  • Genetic polymorphism is the variations in DNA sequences
  • This explain some of the variability in drug- metabolizing enzyme activities which contribute to
  • alterations in drug clearance and
  • impact patients’ response to drug therapy

4. Drug Discovery and Development

  • In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery
  • But now we know diseases are controlled at molecular and physiological level
  • Also shape of an molecule at atomic level is well understood.
  • Information of Human Genome

5. Aptamers Based Drug Delivery

  • Aptamers are oligonucleotide or peptide molecules that bind to specific target molecule.
  • Aptamers are usually created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches.
  • Aptamers can be combined with ribozymes to self-cleave in the presence of their target molecule.
  • They range in size from 20 to 80 bases (6-26kda).

6. Personalized Medicines

  • Personalized medicine. 
  • Dosage forms for personalized medicine. 
  • Categories of patients for personalized medicine.
  • Customized drug delivery systems.
  • 3D printing of pharmaceuticals. 
  • Telepharmacy. 
  • Bioelectric Medicines

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